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Inhibition of COX Isoforms by Nutraceuticals Ben Seaver, PharmD (candidate) Jerry Robert Smith, PhD ABSTRACT. Humans have two isoforms of Prostaglandin H Synthase or cyclooxygenase: COX-1 and COX-2.

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COX-1 Inhibitors DrugTargetTypeIbuprofenThrombomodulintargetIbuprofenFatty acid-binding protein, intestinaltargetIbuprofenPeroxisome proliferator-activated receptor gammatargetIbuprofenCystic fibrosis transmembrane conductance regulatortarget24 more rows

Botanical COX-2 inhibitors block the action of the COX-2 enzyme, which helps reduce inflammation and pain. Turmeric, Ginger, Boswellia, Hops and salicin all have demonstrated anti-inflammatory properties through their role as botanical COX-2 inhibitors.

Curcumin, a popular herbal medicine derived from turmeric, blocks the synthesis of prostaglandins by inhibiting Cyclooxygenase-1 and 2 (COX-1 and COX2).

NSAID inhibition of COX-1 in the stomach can diminish the COX-1 mediated role in gastric mucosal protection, which can lead to GI side effects such as ulcers and bleeding.

Turmeric, Ginger, Boswellia, Hops and salicin all have demonstrated anti-inflammatory properties through their role as botanical COX-2 inhibitors.

Curcumin markedly inhibited the mRNA and protein expression of COX-2, but not COX-1.

Acetylsalicylic acid (aspirin) is a COX-1 inhibitor that inhibits PGH2 and thereby prevents the metabolism of arachidonic acid, which inhibits the production of TXA2. Aspirin irreversibly binds to COX-1, inhibiting TXA2 production for the life of the platelet.

Among the traditional NSAIDs, other then aspirin and , only few examples of selective COX-1 inhibitors (SC-560, FR122047, mofezolac, P6 and TFAP) have been so far identified.

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
Industries
Forms in Spanish
Localized Forms
State-specific Forms
Forms Kit
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232