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Supplemental Material can be found at: http://www.jbc.org/content/suppl/2012/01/05/M111.309526.DC1.html THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 287, NO. 9, pp. 6735 6742, February 24, 2012 2012 by.

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Molecular chaperones facilitate and regulate protein conformational change within cells. This encompasses many fundamental cellular processes: including the correct folding of nascent chains; protein transport and translocation; signal transduction and protein quality control.

Mechanism. The activity of BiP is regulated by its allosteric ATPase cycle: when ATP is bound to the NBD, the SBDα lid is open, which leads to the conformation of SBD with low affinity to substrate. Upon ATP hydrolysis, ADP is bound to the NBD and the lid closes on the bound substrate.

Chaperones play a pivotal role in maintaining cellular homeostasis by assisting other substrate proteins, also known as clients, to fold properly, by stabilizing the intermediates of its clients during folding or intercellular transportation, and by aiding in protein degradation.

BiP, an HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER), binds newly-synthesized proteins as they are translocated into the ER and maintains them in a state competent for subsequent folding and oligomerization.

What appears to be the purpose of molecular chaperones like BiP? They recognize and bind to unfolded or misfolded proteins and help them attain their native structure.

Molecular chaperones facilitate protein folding by binding to and stabilizing unfolded or partially folded polypeptide chains. A protein that facilitates the correct folding or assembly of other proteins. Chaperones also stabilize unfolded polypeptide chains during their transport into organelles.

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Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232