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International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.2, No.1, pp 950-959, Jan-Mar 2010 Evaluation of Some Novel Techniques For Dissolution Enhancement of Poorly Water.

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Examples: Hydrochlorthiazide, , etc. Particle size reduction leads to increase in the effective surface area resulting in enhancement of solubility and dissolution velocity of the drug.

The solubility of poorly soluble drugs can be increased through a variety of methods, including modifying the physical and chemical properties and use of particle size reduction, crystal engineering, salt development, solid dispersion, and surfactants.

In the liquisolid compact, the product particles are first dissolved, partially dissolved or suspended in the non-volatile liquid vehicle and subsequently adsorbed on the suitable carrier and coating excipients to make non-adherent, free flow and compressible powder mixture.

For parenterals, the four most commonly used techniques for solubilization are: pH adjustment; cosolvent addition; micelle inclusion through surfactant addition and complexation.

Liquisolid technique refers to the conversion of liquid medications into apparently dry, non-adherent, free flowing and compressible powder mixtures by blending the liquid medications with suitable excipients, which are generally termed as carriers and coating materials [18], [19].

Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth.

They increase solubility of drug in gastrointestinal tract by increasing the dissolution rate which leads to enhanced absorption of drug and thereby increasing bioavailability.

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© Copyright 1997-2025
airSlate Legal Forms, Inc.
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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232