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Erfor Advanced Biotechnology Department Biomedical and of Engineering, BostonUniversity,Boston,Massachusetts 02215 Sergei M. Mirkin Depa mentGenetics, of University Illinois at Chicago, of Chicago, Illinois 60612 KEY WORDS: triplex, DNA H-DNA, gene-drugs, triplex-forming oligonucleotides, PNA CONTENTS PERSPECTIVESANDSUMMARY ......................................... STRUCTURE, STABILITY, ANDSPECIFICITY OF DNATRIPLEXES ........... Triplex Menagerie .

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DNA topology encompasses supercoiling, knots, and catenanes.

In order to compare levels of supercoiling in molecules of different sizes, the term σ (specific linking difference or more commonly, superhelical density) is utilized. σ is independent of DNA length and can be calculated using the equation: σ = ΔLk ÷ LK0.

They are responsible for unknotting, unlinking, and maintaining the proper supercoiling of DNA during the processes of replication, transcription, and recombination.

DNA topology encompasses supercoiling, knots, and catenanes.

The Linking Number (Lk) of DNA Lk = Tw+Wr Where Tw (twist) is a measure of the helical winding of the DNA strands around each other, and Wr (writhe) is a measure of the coiling of the axis of the double helix.

(A) Supercoiled DNA that just started its process of DNA replication. The molecule is still negatively supercoiled and shows right-handed interwinding. The negative supercoiling helps to initiate the process of DNA replication (7).

The mathematical formula Lk=Tw+Wr can be used to describe this process. Lk, the linking number, represents the number of times one strand winds around the other, Tw is the twist or the amount of rotation about the centre line and Wr, the writhe, describes how hard it is to straighten out the curve.

The linking number is a topological property of DNA. A linking number is a sum of twists and writhes. The number of times one strand of DNA turned around another strand is called a twist while inter-coiling of the double helix is termed as writhe.

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232