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Medical Hypotheses 2006 66 234 246 http //intl.elsevierhealth. com/journals/mehy A tale of two cannabinoids The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol Ethan Russo a b c a b c Geoffrey W. Guy GW Pharmaceuticals Porton Down Science Park Salisbury Wiltshire SP4 0JQ UK University of Washington School of Medicine Seattle WA USA University of Montana Department of Pharmaceutical Sciences MT USA Received 15 August 2005 .

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The CB2 receptors are mainly found on white blood cells, in the tonsils and in the spleen. The immune cells also express CB1, although there are fewer of them than CB2. In the immune system, one important function of the cannabinoid receptors is the regulation of cytokine release.

There are two main endocannabinoid receptors: CB1 receptors, which are mostly found in the central nervous system. CB2 receptors, which are mostly found in your peripheral nervous system, especially immune cells.

Researchers have identified two cannabinoid receptors: CB1, predominantly present in the nervous system, connective tissues, gonads, glands, and organs; and CB2, predominantly found in the immune system and its associated structures.

The therapeutic properties of cannabinoids include anti-inflammatory, neuroprotective, analgesic, antispasmodic, anti-oxidant, antibiotic, anticonvulsive, antiviral, antifungal, bone stimulant, anxiolytic, antipsychotic, vasorelaxant, antidiabetic, antiproliferative, and anti-tumor.

The main cannabinoids are THC and cannabidiol (CBD).

Many of the effects of cannabinoids and endocannabinoids are mediated by two G protein-coupled receptors (GPCRs), CB(1) and CB(2), although additional receptors may be involved. CB(1) receptors are present in very high levels in several brain regions and in lower amounts in a more widespread fashion.

The first discovered and best-characterized endocannabinoids are anandamide (arachidonoyl ethanolamide) and 2-arachidonoyl glycerol (2-AG). An important feature of these endocannabinoids is that their precursors are present in lipid membranes.

THC or Tetrahydrocannabinol is the major psychoactive component and one of the 113 cannabinoids recognized in cannabis. A synthetic formulation of THC, , is FDA approved to manage chemotherapy-induced nausea and vomiting and for appetite stimulation in HIV/AIDS anorexia.

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Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232