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Your tumor cells have enough PD-L1 for you to use immunotherapy medicine, you may be able to start that medicine. This may be called a "positive" test result. Your tumor cells don't have enough PD-L1, then the immunotherapy is not likely to help you. This may be called a "negative" test result.

PD-1 and PD-L1 inhibitors It normally acts as a type of “off switch” that helps keep the T cells from attacking other cells in the body. It does this when it attaches to PD-L1, a protein on some normal (and cancer) cells. When PD-1 binds to PD-L1, it basically tells the T cell to leave the other cell alone.

PD-L1–negative status was a negative prognostic indicator, and was associated with a poor prognosis immune gene signature. Importantly, PD-L1–negative patients had significantly lower levels of somatic mutations when compared with tumors from PD-L1–positive patients.

The co-inhibitory factor PD-1 binds to its ligands, PD-L1 or PD-L2, to transmit inhibitory signals in T cells and anti-apoptotic signals in tumor cells. Thus, PD-1 binding is characterized as one of the major mechanisms of tumor immune escape.

PD-L1 (programmed cell death ligand 1) is a protein that plays a role in the body's immune system. It can bind to another protein called PD-1. When this happens, the two proteins block the immune system from killing cancer cells.

PD-1/PD-L1 inhibitors. Nivolumab (Opdivo), pembrolizumab (Keytruda), and cemiplimab (Libtayo) target PD-1, a protein on certain immune cells (called T cells) that normally helps keep these cells from attacking other cells in the body. By blocking PD-1, these drugs boost the immune response against cancer cells.

Reactive expression of PD-L1 is a favorable event for a cancer cell, as it can specifically inactivate the T cells that are attacking the cancer without inducing a systemic immune-suppressive state (Ribas, 2015).

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© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232
Form Packages
Adoption
Bankruptcy
Contractors
Divorce
Home Sales
Employment
Identity Theft
Incorporation
Landlord Tenant
Living Trust
Name Change
Personal Planning
Small Business
Wills & Estates
Packages A-Z
Form Categories
Affidavits
Bankruptcy
Bill of Sale
Corporate - LLC
Divorce
Employment
Identity Theft
Internet Technology
Landlord Tenant
Living Wills
Name Change
Power of Attorney
Real Estate
Small Estates
Wills
All Forms
Forms A-Z
Form Library
Customer Service
Terms of Service
DMCA Policy
About Us
Blog
Affiliates
Contact Us
Privacy Notice
Delete My Account
Site Map
All Forms
Search all Forms
Industries
Forms in Spanish
Localized Forms
Legal Guides
Real Estate Handbook
All Guides
Prepared for You
Notarize
Incorporation services
Our Customers
For Consumers
For Small Business
For Attorneys
Our Sites
US Legal Forms
USLegal
FormsPass
pdfFiller
signNow
airSlate workflows
DocHub
Instapage
Social Media
Call us now toll free:
1-877-389-0141
As seen in:
  • USA Today logo picture
  • CBC News logo picture
  • LA Times logo picture
  • The Washington Post logo picture
  • AP logo picture
  • Forbes logo picture
© Copyright 1997-2025
airSlate Legal Forms, Inc.
3720 Flowood Dr, Flowood, Mississippi 39232