Shape Equation Release For Free

The simple exponential relation Mt/M? = ktn is introduced to describe the general solute release behavior of controlled release polymeric devices, where Mt/M? is the fractional solute release, t is the release time, k is a constant, and n is the diffusional exponent characteristic of the release mechanism.

First order model: The release of drug can be represented by the equation: DC/dt=-K1C K1 is the first order rate constant, expressed in time-1 or per hour After rearranging and integrating the equation, Log C=log C0-K1t/2.303 C0 is the initial concentration of the drug, C is the percent of drug remaining at time t.

First order model: The release of drug can be represented by the equation: DC/dt=-K1C K1 is the first order rate constant, expressed in time-1 or per hour After rearranging and integrating the equation, Log C=log C0-K1t/2.303 C0 is the initial concentration of the drug, C is the percent of drug remaining at time t.

The concentration in Mol\l recalculate for your volume and multiply by molecular weight, after that you will have the quantity of your substance in grams. Divided it into initial content of this substance in the matrix and multiply by 100. You will have result in %.

The fundamental principle for evaluation of the kinetics of drug release was offered by Noyes and Whitney in 1897 as the equation (10): dM/dt = KS (Cs ? Ct) (1) where M, is the mass transferred with respect to time, t, by dissolution from the solid particle of instanta- neous surface, S, under the effect of the ...

The Higuchi model was originally conceived to describe the release of a drug from a thin ointment film over the skin [16]. It assumes that the initial drug concentration in the film is much higher than the solubility of the drug in the ointment base.

The dissolution of active agents contained in non-disintegrating dosage forms, considering a very slow drug release (with no changes in the equilibrium conditions), can be represented by the equation(5.3) W 0 ? W i = K ? t where W0 is the initial mass of active agent in the dosage form; Wi is the remaining mass in the ...