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Retrospective registration is a registration of a trial after enrollment of the first participant. In general WHO discourages retrospective registration for a number of reasons, although retrospective in a short timeframe (no more than a few weeks from first enrollment) is preferable to no registration at all.

Trial registration creates a public record of all clinical trials that researchers are planning and what they intend to do, e.g. which intervention(s) they will be testing, the comparator(s) they will use, and what outcomes they will be measuring.

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How do I get a Digital Object Identifier (DOI)? You must use a service offered by a DOI Registration Agency (RA). RAs collect metadata, assign DOI names, and offer other services such as reference linking or metadata lookup. See the list of RAs and contact the ones whose services best meet your needs.

Prospective registration is a means to publish details about a research project before its commencement thus allowing evidence users to assess whether all steps of the research have been performed and reported as planned, or not.

Prospective clinical trial registration is a process whereby researchers publicly specify details of trial methodology and conduct before enrolling participants.

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