Plot Release For Free

One is to do the calculations manually Y = log(y) and X = log(x). A plot of Y vs X gives a slope m = n and an intercept b = log(k). The second way is to plot log(y) vs log(x). When you fit a straight line to this plot, the same results are returned for m = n and b = log(k).

Korsmeyer-peppas model: Korsmeyer-peppas model is represented as: Mt/M?=Kkptn Log (Mt/M?) =log Kkp + nlog t Mt/M? is a fraction of drug released at time t, Mt is the amount of drug released in time t, M? is the amount of drug released after time ?, n is the diffusional exponent or drug release exponent, Kkp is the ...

The Korsmeyer-Peppas equation also called "power law" is a semi-empirical model based on the diffusion phenomenon [133] that is used to describe in a general way the main transport phenomena involved in the release, either by diffusion or swelling [134].

The Higuchi model was originally conceived to describe the release of a drug from a thin ointment film over the skin [16]. It assumes that the initial drug concentration in the film is much higher than the solubility of the drug in the ointment base.

Ing to the value 0.574 of coefficient n for the Korsmeyer?Peppas model preparation A releases the active substance both as a result of diffusion and as a result of erosion. Reference values for so-called anomalous transport are within the limits between 0.5 and 1.0.

Cumulative amount of drug released to time graph, represents zero order release and the equation is expressed as, C = K0 t, where K0 is the zero order rate constant and t is the time (in h).

Formula for determination of percentage of release of drug from in vitro dissolution testing Concentration of drug (µg/ml)= (slope × absorbance) ± intercept. Amount of drug = Concentration × Dissolution bath volume × dilution factor.