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T CASE STUDIES "VJCf$' '0 q"'.I3G OFFICE OF INSPECTOR GENERAL OFFICE OF EV ALUA TlON AND INSPECTIONS NOVEMBER 1990 . . . . . . . . .. .. .. .. .. .. .. .. .. .. .. .. .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. .. .. .. .. .. ... . ............ .. .. .. .. .. .. .. TABLE OF CONTENTS INTRODUCTION................................................. . ANALYSIS OF CASE STUDIES...................................... CASE STUDIES Calvin Knowlton and Amh.
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DRGs FAQ
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The composition of the TME varies between tumor types, but hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix (ECM).
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The lung tumour microenvironment (TME) includes a variety of tumour-reprogrammed stromal cells. A major hallmark of immunosuppression in the TME is the inactivation of cytotoxic CD8+T cells, which is achieved through diverse pathways.
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The tumor microenvironment is a complex ecosystem surrounding a tumor, composed of cancer cells, stromal tissue (including blood vessels, immune cells, fibroblasts and signaling molecules) and the extracellular matrix.
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The TME is a critical facilitator of immune escape and cancer progression (Son et al., 2017). The interaction between cancer cells and the diverse cell population within the TME influences tumor resistance, progression and metastasis (Wang et al., 2017).
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The TME refers to the tumor stroma, including fibroblasts, keratinocytes, immune cells, soluble molecules, and extracellular matrix (ECM). The dynamic interaction between the TME and tumor cells is very important for the growth, local invasion, and metastatic spread of tumor cells.
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Tumor microenvironment (TME) is characterized by some special factors such as low extracellular pH, high level of reactive oxygen species, hypoxia, and over-expressed certain proteases in comparison with normal tissue.
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The TME is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.
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TNM stands for Tumour, Node, Metastasis. Doctors might also use a number staging system. Or they might use a scale to describe how deeply the melanoma has grown into your skin. These scales are called the Clark scale and the Breslow scale.
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