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Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

Spastic paralysis can occur when the upper motor neurons become damaged, resulting in a loss of voluntary control over the affected muscles. With spastic paralysis, the signals that tell the muscles to contract or relax are imbalanced. The muscles respond to this by becoming tight and hard.

Symptoms of HSP may begin at any age, from infancy to older than 60 years. If symptoms begin during the teenage years or later, then spastic gait disturbance usually progresses insidiously over many years. Canes, walkers, and wheelchairs may eventually be required.

Most people with pure hereditary spastic paraplegia will have inherited a faulty gene from one of their parents. People with the complicated form of the condition will have usually inherited a faulty gene from both parents. The gene abnormality causes the long nerves in the spine to deteriorate.

The primary symptom of HSP is difficulty walking due to spasticity and weakness in the legs. Both legs are affected, usually to a relatively similar degree. The term “paraplegia” means severe weakness in both legs (similar to “paralysis”).

For SPG4, patients were calculated to live, on average, 24.7 years without symptoms, followed by 56.1 years with symptoms. For SPG11, SPG7, and SPG15, the same approach was followed, resulting in average years lived of 13.0, 36.8, and 14.6 without symptoms, and 60.6, 44.0, and 59.0 with symptoms, respectively (Fig.

Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

Depending on the HSP gene involved, symptoms may begin in childhood or adulthood. There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

Some children with AP-4-HSP have reached their early 20s, but long-term life expectancy for this condition is still unclear, as it was only first recognized in 2011. However, many children with hereditary spastic paraplegias in general have a normal life expectancy.

The prevalence of spastic paraplegia type 4 is estimated to be 2 to 6 in 100,000 people worldwide. This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

Spastic paralysis can occur when the upper motor neurons become damaged, resulting in a loss of voluntary control over the affected muscles. With spastic paralysis, the signals that tell the muscles to contract or relax are imbalanced. The muscles respond to this by becoming tight and hard.

Symptoms of HSP may begin at any age, from infancy to older than 60 years. If symptoms begin during the teenage years or later, then spastic gait disturbance usually progresses insidiously over many years. Canes, walkers, and wheelchairs may eventually be required.

Most people with pure hereditary spastic paraplegia will have inherited a faulty gene from one of their parents. People with the complicated form of the condition will have usually inherited a faulty gene from both parents. The gene abnormality causes the long nerves in the spine to deteriorate.

The primary symptom of HSP is difficulty walking due to spasticity and weakness in the legs. Both legs are affected, usually to a relatively similar degree. The term “paraplegia” means severe weakness in both legs (similar to “paralysis”).

For SPG4, patients were calculated to live, on average, 24.7 years without symptoms, followed by 56.1 years with symptoms. For SPG11, SPG7, and SPG15, the same approach was followed, resulting in average years lived of 13.0, 36.8, and 14.6 without symptoms, and 60.6, 44.0, and 59.0 with symptoms, respectively (Fig.

Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

Depending on the HSP gene involved, symptoms may begin in childhood or adulthood. There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

Some children with AP-4-HSP have reached their early 20s, but long-term life expectancy for this condition is still unclear, as it was only first recognized in 2011. However, many children with hereditary spastic paraplegias in general have a normal life expectancy.

The prevalence of spastic paraplegia type 4 is estimated to be 2 to 6 in 100,000 people worldwide. This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

Spastic paralysis can occur when the upper motor neurons become damaged, resulting in a loss of voluntary control over the affected muscles. With spastic paralysis, the signals that tell the muscles to contract or relax are imbalanced. The muscles respond to this by becoming tight and hard.

Symptoms of HSP may begin at any age, from infancy to older than 60 years. If symptoms begin during the teenage years or later, then spastic gait disturbance usually progresses insidiously over many years. Canes, walkers, and wheelchairs may eventually be required.

Most people with pure hereditary spastic paraplegia will have inherited a faulty gene from one of their parents. People with the complicated form of the condition will have usually inherited a faulty gene from both parents. The gene abnormality causes the long nerves in the spine to deteriorate.

The primary symptom of HSP is difficulty walking due to spasticity and weakness in the legs. Both legs are affected, usually to a relatively similar degree. The term “paraplegia” means severe weakness in both legs (similar to “paralysis”).

For SPG4, patients were calculated to live, on average, 24.7 years without symptoms, followed by 56.1 years with symptoms. For SPG11, SPG7, and SPG15, the same approach was followed, resulting in average years lived of 13.0, 36.8, and 14.6 without symptoms, and 60.6, 44.0, and 59.0 with symptoms, respectively (Fig.

Hereditary spastic paraplegia due to SPG4 gene mutation is the single most common form of autosomal dominant HSP, and possibly the single most common form of any type of HSP.

Depending on the HSP gene involved, symptoms may begin in childhood or adulthood. There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

Some children with AP-4-HSP have reached their early 20s, but long-term life expectancy for this condition is still unclear, as it was only first recognized in 2011. However, many children with hereditary spastic paraplegias in general have a normal life expectancy.

The prevalence of spastic paraplegia type 4 is estimated to be 2 to 6 in 100,000 people worldwide. This condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder.

There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.

There are no treatments to prevent, slow, or reverse HSP. Treatments such as muscle relaxers can sometimes relieve spasticity. Regular physical therapy is important for muscle strength and to keep range of motion.