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Chapter 8 pertaining to Animals be amended as depicted in Exhibit A which replaces the former section found therein. PASSED BY THE CITY COMMISSION OF THE CITY OF GREAT FALLS, MONTANA, this day of , 2006. Dona R. Stebbins, Mayor ATTEST: Peggy J. Bourne, City Clerk (SEAL OF THE CITY) APPROVED FOR LEGAL CONTENT: David V. Gliko, City Attorney State of Montana County of Cascade City of Great Falls ) : ss ) I, Peggy J. Bourne, City Clerk of the City of Great Falls, Montana, do hereby.
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Hereunto FAQ
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Authors Russell and Burch define a replacement technique as “any scientific method employing non-sentient material which may in the history of experimentation replace methods which use conscious living vertebrates.” Scientists should seek to replace animals in experiments with alternatives whenever possible.
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Alternatives to animal experiments Some of the humane alternatives to using animals in experiments: The use of isolated cells and tissues instead of live animals. Using computers and maths. Modelling bio processes and predict the effects of chemicals and drugs.
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Full/Absolute Replacement avoids the use of animals completely. Some examples include training manikins, human tissues and cells, computer models, and microphysiological systems. Partial/Relative Replacement still requires animal use, but the animals do not experience pain or distress during the study.
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Some people contend that many animal experiments could be replaced by experiments that yield the same information without the use of animals. In fact, the present ability to replace animal experiments with alternatives such as tissue cultures, microorganisms, or computer models is very limited.
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An essential advantage of cell culture as an alternative to animal models is that human-based models can be grown by using human cells, thus possibly minimizing the questionable translation of in vitro results to humans.
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Alternative methods do help to reduce the number of animals required for drug research, but there is no way they can completely eliminate the need for animals in preclinical studies.
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The authors proposed the principles of Replacement, Reduction and Refinement - most often referred to as the 3Rs. The principles of the 3Rs are accepted internationally and provide a framework for ethical decision making in the use of animals in research and teaching.
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Examples of refinement include ensuring the animals are provided with housing that allows the expression of species-specific behaviours, using appropriate anaesthesia and analgesia to minimise pain, and training animals to cooperate with procedures to minimise any distress.
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