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Eir research proposals and obtain approval prior to conducting the research. They conduct the research in accordance with the approved research protocol. The Code of Federal Regulations Title 45 Part 46 Protection of Human Subjects (www.nihtraining.com/ohsrsite/guidelines/45cfr46.html) mandating institutional review of research emerged in response to abuse of research participants internationally (the Nuremberg Code, 1949) and in the United States, particularly to the 1972 public disclosure o.

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