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Regulating Axon Branch Stability: The Role Of ... - Stanford University - Stanford
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Opher G. Winter,3 Alison Maresh, Xuesong Zhao, and Liqun Luo1 Department of Biological Sciences Stanford University Stanford, California 94305 Summary Mechanisms that regulate axon branch stability are largely unknown. Genome-wide analyses of Rho GTPase activating protein (RhoGAP) function in Drosophila using RNA interference identified p190 RhoGAP as essential for axon stability in mushroom body neurons, the olfactory learning and memory center. p190 inactivation leads to axon branch retractio.
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Dsrna FAQ
the axon hillock is the site of transition between the cell body and the start of the axon. the change in membrane potential from incoming signals (depolarizations along the dendrites) must reach the 'threshold potential' at the axon hillock in order for an action potential to propagate along the axon.
The bridge between the cell body and the axon is known as the axon hillock. The generation of the action potential occurs at the axon hillock. Most of the neurons possess one key axon and multiple dendrites. The terminal point of the axon is the presynaptic terminal (also referred to as terminal bouton).
Axon Collaterals A collateral branch is an axonal protrusion over10 micrometers in length. These collaterals provide modulation and regulation of the cell firing pattern and represent a feedback system for the neuronal activity. The terminal part of the axon and collaterals tapers progressively.
An axon typically develops side branches called axon collaterals, so that one neuron can send information to several others. These collaterals, just like the roots of a tree, split into smaller extensions called terminal branches. Each of these has a synaptic terminal on the tip.
Summary. An axon is a thin fiber that connects neurons (nerve cells) to that they can communicate. Neurons communicate via electrical impulses that trigger the release of "chemical messengers" called neurotransmitters. Axons also transmit electrical impulses from muscle and gland cells to the brain.
The cone-shaped region of the cell body where the axon originates is termed the axon hillock. This area is free of ribosomes and most other cell organelles, with the exception of cytoskeletal elements and organelles that are being transported down the axon.
Axon terminals are the ends of axons which transmit messages to other cells via use of neurotransmitters at synapses. Meanwhile, axon collaterals are branches off a main axon that allow a neuron to communicate with even more and different types of cells.
The axon hillock is the region of a neuron that controls the initiation of an electrical impulse based on the inputs from other neurons or the environment. The electrical part of the electrochemical signal is called an action potential.
Phosphorylation Related content
Regulating axon branch stability: the role of p190...
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