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Get The Role Of The Lid Element In Transcription By E. Coli RNA ... - Landick Wisc

Cteriology, University of Wisconsin-Madison, Madison, WI 53706, USA The recently described crystal structures of multi-subunit RNA polymerases (RNAPs) reveal a conserved loop-like feature called the lid. The lid projects from the clamp domain and contacts the flap, thereby enclosing the RNA transcript in RNAP's RNA-exit channel and forming the junction between the exit channel and the main channel, which holds the RNA: DNA hybrid. In the initiating form of bacterial RNAP (holoenzyme containing.

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