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Two Forms Of Thymidine Kinase In Normal And Tumor Tissues Of ... - Cancerres Aacrjournals
Get Two Forms Of Thymidine Kinase In Normal And Tumor Tissues Of ... - Cancerres Aacrjournals
Institute of Gerontology, 35-2 Sakae-cho, Itabashhku, Tokyo 173, Japan SUMMARY The thymidine kinases extracted from the spleen of mice infected with Friend virus and from Yoshida sarcoma in rats were separated into two active peaks by diethylaminoethyl cellulose column chromatography, while those of normal tissues have been found to consist of only the first peak (PI). The second peak (P-II) was also found in the enzyme from the extract of the spleen when the animals were treated by i.p. inject.
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Biochemistry. Mammals have two isoenzymes that are chemically very different, Thymidine Kinase 1 (TK1) and Thymidine Kinase 2 (TK2). The former was first found in fetal tissue, the second was found to be more abundant in adult tissue, and so initially they were termed fetal and adult thymidine kinases.
Thymidine kinase is an enzyme involved in the salvage pathway of DNA synthesis and correlates with proliferative activity of tumor cells.
TK1 expression influences pathogenicity by cell cycle progression, cellular migration, and cellular survival in HCC 1806 breast cancer cells. Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
Thymidine kinase is an enzyme involved in the salvage pathway of DNA synthesis and correlates with proliferative activity of tumor cells. From: Abeloff's Clinical Oncology (Fifth Edition), 2014.
Thymidylate kinase (TMPK) is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) in the presence of ATP and Mg(2+) to form thymidine 5'-diphosphate (dTDP), which is then converted to thymidine 5'-triphosphate (dTTP) by nucleoside-diphosphate kinase (NDK).
In mammalian cells, salvage pathway phosphorylation of thymidine is catalyzed by two thymidine kinases: the cell-cycle regulated cytoplasmic TK1 and the constitutively expressed mitochondrial TK2. Since TK1 is virtually absent in non-dividing cells, TK2 is probably the only thymidine kinase present in these cells.
Thymidine kinases have a key function in the synthesis of DNA and therefore in cell division, as they are part of the unique reaction chain to introduce thymidine into the DNA. Thymidine is present in the body fluids as a result of degradation of DNA from food and from dead cells.
Mutations in the thymidine kinase (TK) gene of herpes simplex virus (HSV) may confer resistance to acyclovir (ACV).
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