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A Critical Cytoplasmic Domain Of The Interleukin-5 (IL-5)
Get A Critical Cytoplasmic Domain Of The Interleukin-5 (IL-5)
Iated Growth Signal Transduction SATOSHI TAKAKI, HIROKO KANAZAWA, MASASHI SHIIBA, AND KIYOSHI TAKATSU* Department of Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108, Japan Received 22 June 1994/Returned for modification 25 July 1994/Accepted 22 August 1994 factor (GM-CSF). The cytoplasmic domains of both a and I1 chains are essential for signal transduction. In this study, we generated cDNAs of IL-5Ra having various mutations in their cytoplasmic domains and.
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Chimeric FAQ
IL-5 is a T-cell–derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, activation, and localization of eosinophils. Eosinophils mediate allergic and asthmatic symptoms.
Recently, IL-1 has been recognized as a molecule that is important in the regulation of hematopoiesis. IL-1 induces the production of several different hematopoietic growth factors including granulocyte-macrophage, granulocyte and macrophage colony-stimulating factors and interleukin 6 by a variety of accessory cells.
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils.
It controls hematopoiesis so that it increases natural immunity. In the mouse, IL-5 acts on committed B cells to induce differentiation into Ig-producing cells and on common progenitors for CD5+ pre-B cells and CD5+ macrophages to support their survival.
IL-5 exerts pleiotropic effects on eosinophils, thereby promoting their maturation, activation, survival, migration from bloodstream, and recruitment to airways. IL-5 is a powerful pro-inflammatory cytokine that is responsible for maturation, proliferation, activation, and migration of eosinophils (Figure 1).
While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells including B cells, eosinophils, and basophils.
Recombinant IL-5 activates mouse B cells and eosinophils for their proliferation and differentiation. In humans, the biological effects of IL-5 are best characterized on eosinophils.
IL-5 is a T-cell–derived cytokine involved in the pathogenesis of atopic diseases. It specifically controls the production, activation, and localization of eosinophils. Eosinophils mediate allergic and asthmatic symptoms.
FDC Related content
A critical cytoplasmic domain of the interleukin-5...
by S Takaki · 1994 · Cited by 164 — Abstract. Interleukin-5 (IL-5) regulates the...
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