Get Active Cystathionine -Synthase Can Be Expressed In Heme-free ... - Jbc

Hyperhomocysteinemia and low levels of cysteine associated with various diseases like cardiovascular diseases (CVD), ischemic stroke, neurological disorders, diabetes, cancer like lung and colorectal cancer, renal dysfunction-linked conditions, and vitiligo.

Cystathionine-gamma-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis. Angiotensin II downregulates vascular endothelial cell hydrogen sulfide production by enhancing cystathionine gamma-lyase degradation through ROS-activated ubiquitination pathway.

Rich food sources of cysteine are poultry, egg, beef, and whole grains. 6 As consumption of red meat and processed meat is positively associated with risk of stroke,13 dietary cys- teine should preferably be obtained from nonmeat sources.

Sources of Cysteine Mainly in the liver, from homocysteine issued from the transmethylation of methionine, cysteine can be endogenously synthesized. Our body cysteine is created from methionine, an essential amino acid.

There is no specific dietary recommendation for cysteine because your body can produce small amounts. For your body to make the amino acid cysteine, you need adequate amounts of folate, vitamin B6, and vitamin B12. These nutrients can be found in beans, lentils, spinach, bananas, salmon, and tuna.

Deficiency Factors Dietary deficiency of vitamin B6, vitamin B12, folic acid, methionine and s-adenosyl methionine (SAMe) can lead to a deficiency of cysteine since these nutrients are involved in its production in the body.