Get A Combination Of Autoantibodies To Cyclic ... - BioMed Central

This blood test checks for an amino acid called citrulline. Citrulline is present when you have rheumatoid arthritis (RA). RA occurs when your immune system attacks normal cells in your joints. Citrulline is a byproduct of joint damage.

If you have symptoms of rheumatoid arthritis, and your results show: Positive CCP antibodies and positive RF, it likely means that you have rheumatoid arthritis. Positive CCP antibodies and negative RF, it may mean you are in the early stages of rheumatoid arthritis or will develop it in the future.

Is anti-CCP specific to RA? A positive anti-CCP result likely means a person has RA, but it is not specific to RA alone. In a 2020 study , researchers note that it is possible for anti-CCP to be present in people with other diseases, such as tuberculosis, autoimmune hepatitis, and systemic lupus.

Rheumatoid factor (RF) is a reactive IgM autoantibody which is positive in approximately 80% of patients within one year of presentation of rheumatoid arthritis (RA), but in only 30% at the onset of arthritis. Anti-CCP (cyclic citrullinated peptide) is an autoantibody which appears early in the course of RA.

The anti – CCP test normal range is less than 20 u/ml. A level above 20 is indicative of the possibility of Rheumatoid Arthritis. These anti -CCP's are proteins produced by the immune system in response to perceived threat from citrulline.

Background: Anti-cyclic citrullinated peptide (anti-CCP) antibodies have proved to be a specific marker for the diagnosis of rheumatoid arthritis (RA). However, the antibodies can also be detected in other rheumatic diseases, especially systemic lupus erythematosus (SLE).

The presence of anti-CCP antibodies is associated with immune-mediated connective tissue disorders; however, the association with arthritis is more significant. Anti-CCP antibodies, thought to be a marker for RA till now, are shown in our study to be elevated in other disorders also.

Anti-cyclic citrullinated peptide (anti-CCP) is widely used as as a marker, particularly for rheumatoid arthritis (RA), and may be positive in some diseases that also cause arthritis, such as systemic lupus erythematosus, familial Mediterranean fever, Behçet's disease, and psoriatic arthritis.