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Diffusion Of Macromolecules And Virus-Like Particles In Human Cervical Mucus - Ncbi Nlm Nih
Get Diffusion Of Macromolecules And Virus-Like Particles In Human Cervical Mucus - Ncbi Nlm Nih
Kevin J. Whaley,* Thomas R. Moench, and Richard A. Cone* *Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, 21218, Department of Obstetrics and Gynecology, UC Davis School of Medicine, University of California-Davis, California, Epicyte Pharmaceutical, Inc., San Diego, California, and ReProtect, LLC, Baltimore, Maryland USA ABSTRACT To determine whether or not large macromolecules and viruses can diffuse through mucus, we observed the motion of protei.
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1998 FAQ
Both mucus and biofilms have viscoelastic properties that are heavily influenced by the concentration and composition of polymeric substances (4, 11). For mucus, those polymers include DNA, which is released into the airway as a result of the chronic inflammatory response and mucins (16, 17).
Thus, diffusion in entangled DNA solutions strongly depends on topology of both the diffusing molecule and the surrounding molecules. This effect also strongly depends on DNA concentration and length.
DNA contains the instructions needed for an organism to develop, survive and reproduce. To carry out these functions, DNA sequences must be converted into messages that can be used to produce proteins, which are the complex molecules that do most of the work in our bodies.
In aqueous solutions, diffusion coefficients of the DNA fragments in water (Dw) decreased from 53 × 10−8 to 0.81 × 10−8 cm2/s for sizes of 21–6000 bp; D w was related empirically to DNA size:D.
DNA now has three distinct functions—genetics, immunological, and structural—that are widely disparate and variously dependent on the sugar phosphate backbone and the bases.
The mucosal immune system actively transports large quantities of antibodies into all mucus secretions, and these secreted antibodies help prevent infectious entry of many pathogens.
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