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Ed Hydroxylation and Carboxylic Acid Ester Cleavage of Hantzsch Pyridine Esters* (Received for publication, November 30, 1987) F. Peter GuengerichS, Lisa A. Peterson#, andRonald H. Biickern From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 Cytochrome P-450 (P-45O)-catalyzed oxidation of 1,4-Dihydropyridine Hantzsch estershave been used exten2,6-dimethyl-4-phenyl-3,6-pyridinedicarboxylic acid sively as ca.

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