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RIK DE CLERCQ* Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium primarily in the treatment of some hemorrhagic fever virus infections (e.g., Lassa fever) and respiratory syncytial virus infections. Although (in aerosolized form) has been approved for the latter indication (in 1985), its effectiveness has remained controversial (70). In retrospect, it can be stated that antiviral chemotherapy came of age with the advent in 1977 of acyclovir 9.
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- transcriptase
- deoxyuridine
- PMPA
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