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Covalently Closed Circular DNA Is The Predominant Form Of Duck ... - Jvi Asm
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All Rights Reserved. Vol. 79, No. 19 Covalently Closed Circular DNA Is the Predominant Form of Duck Hepatitis B Virus DNA That Persists following Transient Infection Marc F. Le Mire,1 Darren S. Miller,1 Wendy K. Foster,1 Christopher J. Burrell,1,2 and Allison R. Jilbert1,2* School of Molecular and Biomedical Science, University of Adelaide, North Terrace, Adelaide, South Australia 5005, Australia,1 and Infectious Diseases Laboratories, Institute of Medical and Veterinary Science, Frome Road.
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Virions FAQ
The cccDNA is a special, ring-shaped DNA structure that appears in the cell nucleus during the replication of some viruses and can persist there. Synonyms. covalently closed circular DNA.
Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is a key form of the virus responsible for its persistence and is the transcriptional template for all viral transcripts.
Hepatitis B virus (HBV) contains a small, partially double-stranded, relaxed circular (RC) DNA genome. RC DNA needs to be converted to covalently closed circular (CCC) DNA, which serves as the template for all viral RNA transcription.
The persistence of covalently closed circular DNA (cccDNA) in infected hepatocytes is the major barrier preventing viral eradication with existing therapies in patients with chronic hepatitis B. Therapeutic agents that can eliminate cccDNA are urgently needed to achieve viral eradication and thus HBV cure.
cccDNA (covalently closed circular DNA) is a special DNA structure that arises during the propagation of some viruses in the cell nucleus and may remain permanently there. It is a double-stranded DNA that originates in a linear form that is ligated by means of DNA ligase to a covalently closed ring.
HBV is a small virus that persists as an episome, covalently closed circular DNA (cccDNA) in the nucleus of infected cells.
cccDNA (covalently closed circular DNA) is a special DNA structure that arises during the propagation of some viruses in the cell nucleus and may remain permanently there. It is a double-stranded DNA that originates in a linear form that is ligated by means of DNA ligase to a covalently closed ring.
Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is formed by conversion of capsid-associated relaxed circular DNA (rcDNA) via unknown mechanisms and exists in the nucleus of the infected hepatocyte as a minichromosome that serves as the transcription template for viral RNAs.
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