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The sources of natural anti-cancer agents, including curcumin, (-)-epigallocatechin-3-gallate, resveratrol, indole-3-carbinol, and vitamin D, chrysin, celastrol and betulinic acid.

There are four classes of plant-derived anticancer agents in the market today, the vinca alkaloids (, and vindesine), the epipodophyllotoxins ( and ), the taxanes ( and ) and the camptothecin derivatives (camptotecin and ).

(), for example, one of the most commonly used chemotherapy drugs, was derived from the bark of the Pacific yew tree; , one of the first antibiotics, from a mold; and drugs to lower cholesterol from compounds found in fungi.

Compounds like curcumin, resveratrol, apigenin, berberine, vinca alkaloids, taxanes etc. isolated from various plants extracts have shown anticancer activity against different types of cancers.

Chemicals extracted from clippings of Taxus brevifolia (Pacific yew) have been used as the basis for two chemotherapy drugs, and . emtansine (Kadcyla) is an antibody conjugated to a synthetic derivative of the cytotoxic principle of the Ethiopian plant Maytenus ovatus.

For centuries, plants have been exploited by mankind as sources of numerous cancer chemotherapeutic agents. Good examples of anticancer compounds of clinical significance today include the taxanes (e.g., ), , , and the podophyllotoxin analogues that all trace their origin to higher plants.

For centuries, plants have been exploited by mankind as sources of numerous cancer chemotherapeutic agents. Good examples of anticancer compounds of clinical significance today include the taxanes (e.g., ), , , and the podophyllotoxin analogues that all trace their origin to higher plants.

Semisynthetic podophyllotoxin derivatives, i.e. and , also called lignans, are important plant-derived cytostatics. They are derived from Podophyllum pelatum and Podo- phyllum emodi.